Slide 61-Ileum: lymphoid nodules (Peyer's patches)

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Higher-power views of the mucosa over Peyer’s patches sometimes show M cells.  These epithelial cells are flattened in contrast to the typical simple columnar epithelium of the digestive tract.  A region with M cells is seen overlying a lymphocytic infiltrate at the bottom of this image.  Look for the stretch of epithelium that lacks goblet cells.