st. john's wort
Reported Uses | Scientific Evidence | Adverse Effects| References
Scientific Names: hydrastis canadensis
Common Names: eye balm, eye root, goldsiegel, ground raspberry, indian dye, indian turmeric, jaundice root, orange root, turmeric root, yellow paint, yellow puccoon, wild curcuma
Goldenseal is a perennial found in the Ohio River Valley. Due to overuse, goldenseal is becoming endangered in the wild, with efforts underway to cultivate the botanical.10 The combination herbal supplement of echinacea and goldenseal has emerged as one of the top five herbal supplements sold in the world-wide market with sales in the US close to $50,000,000 annually.5. Despite its popularity, much of the peer reviewed literature available on goldenseal deals specifically with the plant alkaloid component berberine, and not the herbal supplement itself.
1. [no authors listed]. Berberine. Altern Med Rev. 2000;5:175-177.
2. Akhter MH, Sabir M, Bhide NK. Possible mechanism of antidiarrhoel effect of berberine. Indian J Med Res. 1979;70:233-241.
3. Choudhry VP, Sabir M, Bhide VN. Berberine in giardiasis. Indian Pediatrics. 1972;9:143-146.
4. Chun YT, Yip TT, Lau KL, Kong YC. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmacol. 1978;10:177-182.
5. Govindan M, Govindan G. A convenient method for the determination of the quality of goldenseal. Fitoterapia. 2000;71:232-235.
6. Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulfate on the growth and structure of entamoeba histolytica, giardia lamblia, and trichomonas vaginalis. Ann Trop Med Parasitol. 1991;85:417-425.
7. Khosla PK, Neeraj VI, Gupta SK, Satpathy G. Berberine, a potential drug for trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992;69:147-165.
8. Marin-Neto JA, Maciel BC, Secches AL, Gallo L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clinical Cardiology. 1988;11:253-260.
9. Sack RB, Froelich JL. Berberine inhibits intestinal secretory response of vibrio cholera and escherichia coli enterotoxins. Infectious Immunology. 1982;35:471-475.
10. Skidmore-Roth L. Mosby's handbook of herbs and natural supplements. St. Louis: Elsevier Science Imprints. 2001.